What Are the Challenges in Targeting Fatty Acid Biosynthesis?
Despite its potential, targeting fatty acid biosynthesis presents several challenges. First, some pathogens can scavenge fatty acids from their host, reducing their dependence on endogenous fatty acid synthesis. Second, the redundancy and plasticity in the fatty acid biosynthesis pathways of some pathogens may render single-target therapies less effective. Additionally, the development of resistance to fatty acid biosynthesis inhibitors can occur, necessitating combination therapies.
