Despite their effectiveness, ACTs face several challenges:
1. Drug Resistance: There is growing concern about the emergence of [artemisinin resistance](https://) in certain regions, particularly in Southeast Asia. This resistance reduces the effectiveness of ACTs and threatens global malaria control efforts. 2. Adherence: Ensuring patients complete the full course of treatment is crucial for the success of ACTs. Incomplete adherence can lead to treatment failure and the development of resistance. 3. Access and Cost: In many malaria-endemic regions, access to ACTs can be limited due to cost, supply chain issues, and healthcare infrastructure challenges.
