Can Folate Biosynthesis Inhibition be Used Against All Pathogens?
Not all pathogens are susceptible to folate biosynthesis inhibitors. For example, Mycobacterium tuberculosis, the causative agent of tuberculosis, has a different set of enzymes and regulatory mechanisms that make it less susceptible to traditional folate inhibitors. Thus, while folate biosynthesis remains a valid target, its effectiveness varies depending on the pathogen.
