Despite its successes, the RBM Partnership faces several challenges, including: - Insecticide and Drug Resistance: The emergence of resistance to insecticides and antimalarial drugs threatens the effectiveness of current interventions. - Funding Gaps: There is a continuous need for sustainable funding to ensure the scale-up and maintenance of malaria control efforts. - Health System Weaknesses: Limited infrastructure, workforce shortages, and supply chain issues can hinder the delivery of malaria interventions. - Changing Epidemiology: Climate change, urbanization, and population movements can alter malaria transmission patterns, requiring adaptive strategies.