What Are the Challenges in Targeting the Apicoplast?
One of the main challenges in targeting the apicoplast is the development of drug resistance. Parasites can evolve mechanisms to bypass the need for certain functions of the apicoplast, rendering some drugs ineffective. Moreover, the complex biology of the apicoplast, including its distinct set of genes and metabolic pathways, requires a deep understanding to develop effective drugs. Another challenge is ensuring that drugs can selectively target the apicoplast without affecting similar pathways in the human host, thus minimizing potential side effects.
