Several challenges exist in the realm of antimalarial therapy, including:
Drug Resistance: The emergence of drug-resistant strains of Plasmodium, particularly to chloroquine and sulfadoxine-pyrimethamine, has significantly affected treatment efficacy. Access to Medications: In many endemic regions, access to effective antimalarial drugs is limited due to logistical, economic, and infrastructural barriers. Side Effects: Some antimalarial drugs can cause significant side effects, which may limit their use in certain populations.