Histone deacetylase inhibitors (HDAC inhibitors) are a class of compounds that interfere with the function of histone deacetylase. These enzymes play a critical role in the regulation of gene expression by removing acetyl groups from histone proteins. This action impacts the winding and unwinding of DNA, thereby influencing which genes are transcribed. HDAC inhibitors have primarily been researched in the context of cancer, but they are increasingly being explored for their potential in treating infectious diseases.