Perforin Modulators - Infectious Diseases

Relevant Publications

TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells.

Issue Release: 2020

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.

Issue Release: 2020

Serum immune modulators during the first cycle of anti-PD-1 antibody therapy in non-small cell lung cancer: Perforin as a biomarker.

Issue Release: 2020

Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis.

Issue Release: 2017

Sickle cells produce functional immune modulators and cytotoxics.

Issue Release: 2017

Influence of photodynamic therapy on peripheral immune cell populations and cytokine concentrations in head and neck cancer.

Issue Release: 2017

Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy.

Issue Release: 2016

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Issue Release: 2015

Keeping Off the Weight with DCs.

Issue Release: 2015

Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR.

Issue Release: 2011

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.

Issue Release: 2011

The proposed mechanism of action during different pain management techniques on expression of cytolytic molecule perforin in patients after colorectal cancer surgery.

Issue Release: 2010

In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice.

Issue Release: 2008

Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan.

Issue Release: 2003

Prevention of antigen-induced microtubule organizing center reorientation in cytotoxic T cells by modulation of protein kinase C activity.

Issue Release: 1998

Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.

Issue Release: 1996

Cytokine mRNA profiles in mononuclear cells in acute aseptic meningoencephalitis.

Issue Release: 1995

Role of apoptosis and proteolysis in the pathogenesis of iliac artery aneurysms.

Issue Release: 0000

How Common is Asymptomatic Infection?

How can individuals protect themselves from HIV?

What is Hepatitis B?

Are There Any Complications?

How Does Parasite DNA Contribute to Drug Resistance?

What is the Role of Pharmacovigilance?

How is Gene Therapy Applied in Infectious Diseases?

Can Asymptomatic Individuals Develop Symptoms Later?

Are There Any Technological Advances in Hygiene Practices?

How is Efficacy Measured?

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