Zhijian ’james’ Chen - Infectious Diseases

Author Information

Zhijian J. Chen is a distinguished researcher affiliated with the Department of Molecular Biology at the University of Texas Southwestern Medical Center in Dallas, TX. Renowned in the field of molecular biology and infectious diseases, he has made substantial contributions to our understanding of the mechanisms underlying innate immunity and related biological processes.

Research Contributions

Zhijian J. Chen has made significant strides in the study of innate immunity, particularly focusing on the role of cGAS-STING pathway in immune defense and autoinflammatory diseases. His work has elucidated critical interactions between immune sensors and signaling pathways, as evidenced by his research on TBK1 recruitment to STING and its implications in autoinflammatory arthritis and cancer. Additionally, Chen has contributed to understanding the molecular mechanisms by which viruses such as SARS-CoV-2 disrupt host cellular machinery, providing insights crucial for developing therapeutic strategies.

Aliases

Zhijian J. Chen is known by several aliases in the scientific community, including Zhijian James Chen, Zhijian ‘james’ Chen, and Zhijian Chen, among others. These variations are used interchangeably in publications and citations.

Publication and Citation Metrics

Metric	Value
Total Number of Papers	253
Total Citation Count	64,942
h-index	107

Publications:

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance

DOI: 10.1084/jem.20211539

Year: 2022

Editorial overview: Four dimensions of innate immunity.

DOI: 10.1016/j.coi.2022.102174

Year: 2022

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DOI: 10.1080/15548627.2020.1797280

Year: 2021

cGAS restricts colon cancer development by protecting intestinal barrier integrity

DOI: 10.1073/pnas.2105747118

Year: 2021

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

DOI: 10.1101/2021.10.25.465197

Year: 2021

Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS

DOI: 10.1093/nar/gkab689

Year: 2021

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

DOI: 10.1073/pnas.2100225118

Year: 2021

Phosphorylation and Chromatin Tethering Prevent cGAS activation During Mitosis

DOI: 10.1126/science.abc5386

Year: 2021

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

DOI: 10.1126/sciadv.abe7386

Year: 2021

STEEP mediates STING ER exit and activation of signaling

DOI: 10.1038/s41590-020-0730-5

Year: 2020

Can Personal Hygiene Impact Infectious Disease Spread?

What Are the Treatment Options for Immunodeficiency Disorders?

What is Hepatitis B?

Do Condoms Have Any Limitations?

What are the Prevention Strategies?

How Can Quarantine be Effectively Implemented?

How Does Lipid Metabolism Influence Pathogen Resistance?

How Can These Diseases Be Prevented?

What Are the Main Components of the Immune System?

Are There Any Emerging Technologies in Mosquito Control?

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