L. C. J. Abel - Infectious Diseases

Author Information

Laurent Abel is a prominent researcher affiliated with the Laboratory of Human Genetics of Infectious Diseases at the Necker Branch of the Institut National de la Santé et de la Recherche Médicale U1163 in Paris, France. His work primarily focuses on understanding the genetic and immunological factors that contribute to infectious diseases, with a particular emphasis on how genetic variants can influence susceptibility to severe viral infections, such as COVID-19.

Research Contributions

Laurent Abel has significantly contributed to the field of infectious diseases, particularly in understanding the genetic basis of immune responses to viral infections. His recent work includes identifying genetic variants that affect immune function and influence the severity of viral diseases, such as a loss-of-function IFNAR1 allele in Polynesia and a common TMPRSS2 variant providing protection against severe COVID-19. Abel's research also explores the role of autoantibodies in COVID-19 mortality and the impact of genetic deficiencies on immune responses.

Aliases

Laurent Abel is also known by the aliases L Abel, L. Abel, L. C. J. Abel, and L. Abel.

Publication and Citation Metrics

Metric	Value
Total Citations	44,577
H-index	114
Total Publications	546

Publications:

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.

DOI: 10.1084/jem.20220028

Year: 2022

A common TMPRSS2 variant has a protective effect against severe COVID-19

DOI: 10.1016/j.retram.2022.103333

Year: 2022

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies

DOI: 10.21203/rs.3.rs-1225906/v1

Year: 2022

Low Lymphocytes and IFN-Neutralizing Autoantibodies as Biomarkers of COVID-19 Mortality

DOI: 10.1007/s10875-022-01241-5

Year: 2022

Genome-wide detection of human variants that disrupt intronic branchpoints

DOI: 10.1101/2022.04.18.488668

Year: 2022

Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

DOI: 10.1007/s10875-021-01036-0

Year: 2021

Genetic, Immunological, and Clinical Features of 32 Patients with Autosomal Recessive STAT1 Deficiency

DOI: 10.4049/jimmunol.2001451

Year: 2021

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency.

DOI: 10.1084/jem.20210566

Year: 2021

Inherited GATA2 Deficiency Is Dominant by Haploinsufficiency and Displays Incomplete Clinical Penetrance

DOI: 10.1007/s10875-020-00930-3

Year: 2021

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

DOI: 10.1084/jem.20202726

Year: 2021

How Do Viruses Spread?

What are the Challenges in Managing Ebola?

What Are the Symptoms of Diseases Transmitted by Culex?

How are Antimalarial Drugs Used?

How Does Inherited Immunity Work?

How Are Infectious Diseases Transmitted?

What Role Does the Immune System Play?

What Are the Challenges in Implementing AI?

What is Real-Time PCR?

Why are Structural Proteins Important in Infectious Diseases?

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