K. C. Chadee - Infectious Diseases

Author Information

Kris Chadee is a distinguished researcher affiliated with the Department of Microbiology, Immunology and Infectious Diseases at the University of Calgary, specifically within the Gastrointestinal Research Group at the Snyder Institute for Chronic Diseases. Based in Calgary, Alberta, Canada, Chadee's work focuses on the intricate interactions between pathogens and the human host, with particular emphasis on intestinal diseases and immune responses.

Research Contributions

Kris Chadee has significantly contributed to the field of infectious diseases, with a focus on gut pathogens and the immune system's response to these threats. Notable areas of his research include the role of goblet cells in mucin production under stress, the interaction of mucin with pathogens like Salmonella typhimurium, and the complex mechanisms by which pathogens such as Entamoeba histolytica and Giardia duodenalis manipulate host immune responses. His work also explores the modulation of inflammation and barrier integrity in inflammatory bowel diseases (IBD) through dietary fibers and the NF-κB signaling pathway. Chadee's research is pivotal in understanding how pathogens evade immune responses and how the host can counteract these strategies.

Aliases

Kris Chadee is also known by several aliases in academic publications, including K Chadee, K C Chadee, and K. C. Chadee. These variations may appear across different journals and databases.

Publication and Citation Metrics

Metric	Value
Total Papers	248
Citation Count	8651
H-Index	51

Publications:

A43 HIGH MUC2 MUCIN BIOSYNTHESIS BY GOBLET CELLS UNDER METABOLIC STRESS PRODUCE ELEVATED LEVELS OF PRO-INFLAMMATORY CYTOKINES

DOI: 10.1093/jcag/gwab049.042

Year: 2022

A198 COLONIC MUC2 MUCIN IS STABILIZED BY FCGBP TO RESIST SALMONELLA TYPHIMURIUM INVASION IN GOBLET CELLS

DOI: 10.1093/jcag/gwab049.197

Year: 2022

Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression.

DOI: 10.1016/j.ijpara.2021.11.011

Year: 2022

A63 THE COLONIC PATHOGEN, ENTAMOEBA HISTOLYTICA ACTIVATES CASPASE-4 IN HUMAN MACROPHAGES THAT CLEAVES GASDERMIN D TO FACILITATE IL-1β SECRETION IN THE ABSENCE OF CELL DEATH

DOI: 10.1093/jcag/gwab049.062

Year: 2022

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion

DOI: 10.1371/journal.ppat.1010415

Year: 2022

609 ELUCIDATING THE COMPLEX ROLE OF DIETARY FIBERS IN MEDIATING INFLAMMATION AND BARRIER INTEGRITY IN IBD

DOI: 10.1016/S0016-5085(21)01041-6

Year: 2021

A50 MODULATION OF GOBLET CELL ACTIVITY DURING GIARDIA DUODENALIS INFECTION: A ROLE FOR PAR2

DOI: 10.1093/JCAG/GWAB002.048

Year: 2021

Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages

DOI: 10.1371/journal.ppat.1009936

Year: 2021

A31 COMPLEX ROLE OF DIETARY FIBERS IN IBD: MICROBES MEDIATE FIBER-INDUCED INFLAMMATION

DOI: 10.1093/JCAG/GWAB002.030

Year: 2021

The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites

DOI: 10.3389/fcimb.2021.748404

Year: 2021

What are Common Adverse Effects of Antimicrobial Drugs?

What About the Use of Condoms and Lubricants?

How Can Personal Hygiene Help in Infection Prevention?

Why is the Global Fund Important?

What Causes Vaccine Hesitancy?

How is Quarantine Different From Isolation?

Are There Metabolic Pathway Differences Between Pathogens and Hosts?

Are There Any Limitations to Wearing Masks?

How to Apply Insect Repellent Effectively?

What Treatments are Available for Dengue?

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