Gregory B. Melikyan - Infectious Diseases

Author Information

Gregory B. Melikyan is an esteemed researcher in the field of Infectious Diseases, currently affiliated with the Department of Pediatrics at Emory University, Atlanta, Georgia. His research primarily focuses on viral entry mechanisms and the interactions between viral components and host cellular factors. Through his work, Dr. Melikyan has significantly contributed to the understanding of viral fusion processes and host-virus interactions, which are critical in the development of therapeutic interventions for viral infections.

Research Contributions

Dr. Gregory B. Melikyan has made substantial contributions to the field of virology, with a focus on the mechanisms of viral entry and fusion. His recent research includes studies on Lassa virus fusion, where he identified the role of endosome-resident lipids as cofactors in the fusion process. He has also explored the inhibitory effects of human defensins on SARS-CoV-2 infection and investigated the role of host factors such as Sec24C in HIV-1 replication. His work has provided valuable insights into the interactions between viruses and host cellular components, which are crucial for developing antiviral strategies.

Aliases

Throughout his academic career, Dr. Gregory B. Melikyan has been referenced by various names, including Gregory Melikyan, G. B. Melikyan, and G Melikyan. These aliases are used interchangeably in scientific literature and databases.

Publication and Citation Metrics

Metric	Value
Citation Count	4186
h-index	34
Paper Count	96

Publications:

Post-hemifusion stages of Lassa virus GPC-mediated fusion with endosomes are augmented by a late endosome-resident lipid

DOI: 10.1016/j.bpj.2021.11.2348

Year: 2022

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

DOI: 10.3390/v13071246

Year: 2021

The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion

DOI: 10.1101/2021.03.22.436413

Year: 2021

Sec24C is an HIV-1 host dependency factor crucial for virus replication

DOI: 10.1038/s41564-021-00868-1

Year: 2021

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Altering Mechanical Properties of Cell Membranes.

DOI: 10.1021/acsnano.0c10567

Year: 2021

The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion

DOI: 10.1371/journal.ppat.1009488

Year: 2021

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Locally Altering Mechanical Properties of Cell Membranes

DOI: 10.1016/J.BPJ.2020.11.2024

Year: 2021

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

DOI: 10.1038/s41467-020-17256-8

Year: 2020

Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters.

DOI: 10.1021/acsnano.0c02699

Year: 2020

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

DOI: 10.3390/v12111234

Year: 2020

Why Are Functional Assays Important?

Can Symptomatic Relief Replace Primary Treatment?

How Are STIs Transmitted?

How do emerging infectious diseases pose a threat?

Are There Diagnostic Implications?

How is HFMD Transmitted?

Are There Vaccines Available for Diseases Transmitted by Aedes Aegypti?

What Are the Key Components of a One Health Approach?

What are the limitations of RT-PCR?

How Do Airborne Diseases Differ from Droplet Transmission?

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