Atovaquone Proguanil - Infectious Diseases

What is Atovaquone Proguanil?

Atovaquone proguanil is a combination medication used primarily for the prevention and treatment of malaria, an infectious disease caused by Plasmodium parasites transmitted through the bites of infected Anopheles mosquitoes. This combination is marketed under the brand name Malarone, among others, and is known for its efficacy in both preventing malaria and treating uncomplicated cases.

How Does Atovaquone Proguanil Work?

The combination of atovaquone and proguanil works synergistically to inhibit the growth and reproduction of the malaria parasite. Atovaquone interferes with the electron transport chain in the mitochondria of the parasite, thereby disrupting its energy production. Proguanil is a prodrug converted into cycloguanil, which inhibits dihydrofolate reductase, an enzyme critical for DNA synthesis and cell multiplication in the parasite. Together, they effectively target both the blood stages of the parasite's lifecycle and provide a robust defense against infection.

What are the Indications for Use?

Atovaquone proguanil is indicated for the prophylaxis and treatment of Plasmodium falciparum malaria, including strains resistant to other antimalarial drugs. It is especially useful for travelers to regions where the malaria parasite is resistant to other medications like chloroquine. The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recommend this combination for travelers heading to high-risk areas.

Who Should Not Use Atovaquone Proguanil?

This medication is contraindicated in individuals with severe renal impairment (creatinine clearance

Relevant Publications

Late Parasitological Failure and Subsequent Isolated Gametocytemia of Uncomplicated Malaria in a Returned Traveler From Ghana, 2023.

Issue Release: 2024

[Gastrointestinal symptoms may reflect complicated falciparum malaria].

Issue Release: 2024

Atovaquone-Proguanil: A Promising Therapy for Persistent Relapsing Babesiosis.

Issue Release: 2024

Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine.

Issue Release: 2024

Tafenoquine for Relapsing Babesiosis: A Case Series.

Issue Release: 2024

Plasmodium knowlesi Infection in Traveler Returning to Canada from the Philippines, 2023.

Issue Release: 2023

Evaluation of CYP2C19-Mediated Pharmacokinetic Drug Interaction of Tegoprazan, Compared with Vonoprazan or Esomeprazole.

Issue Release: 2023

Hair concentrations of anti-malarials in returned travellers-the HAIR study: Proof of principle analysis.

Issue Release: 2023

Symptoms of illness during travel and risk factors for non-adherence to malaria prophylaxis-a cross-sectional study in travellers from Germany.

Issue Release: 2023

Artemether-lumefantrine, mefloquine and atovaquone-proguanil in the treatment of uncomplicated Plasmodium falciparum malaria in travellers: A retrospective comparative study of efficacy and treatment failures.

Issue Release: 2023

Transmissibility of clinically relevant atovaquone-resistant by anopheline mosquitoes.

Issue Release: 2023

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial.

Issue Release: 2023

Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria.

Issue Release: 2023

Creating and Validating Ligase Primers to Detect Single Nucleotide Polymorphisms Associated with Atovaquone Resistance in Plasmodium falciparum.

Issue Release: 2023

Weight-related malaria treatment failure with artemether-lumefantrine.

Issue Release: 2023

Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum.

Issue Release: 2023

A Safe and Effective Atovaquone-Proguanil Therapeutic Protocol for the Treatment of Avian Malaria by in Snowy Owl ().

Issue Release: 2023

Polymicrobial Infection in an Immigrant Female at the United States-Mexico Border.

Issue Release: 2023

Tolerability of Atovaquone-Proguanil Application in Common Buzzard Nestlings.

Issue Release: 2022

Global scenario of Plasmodium vivax occurrence and resistance pattern.

Issue Release: 2022

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